Zen Habits has a very good list of things that will help you simplify your work day.

Most of these I’ve seen before, but here’s a new one (which is sort of similar to other things I’ve seen, but different enough I thought it was worth quoting):

# Practice a focus ritual. Every hour or two, do a refocus ritual. This only takes a minute or two. You might start it by closing down your browser and maybe other open applications, and maybe even take a walk for a couple of minutes to clear your head and get your blood circulating. Then return to your list of Most Important Tasks and figure out what you need to accomplish next. Before you check email again or go back online, work on that important task for as long as you can. Repeat this refocus ritual throughout the day, to bring yourself back. It’s also nice to take some nice deep breaths to focus yourself back on the present.